This decision comes after the team's defeat to Real Oviedo in the LaLiga promotion playoff on Saturday.
Lisci had been in charge of Mirandes for two seasons, guiding the team through 88 games overall.
Both Mirandes and Lisci have agreed to end their association by mutual decision.
As one of Mirandes' most successful coaches, Lisci will be remembered for his contributions to the team.
Mirandes has expressed their gratitude to Lisci, stating: "Thank you for everything, coach. You will always be part of our club's history."
