Isak, who is currently on strike, has been seeking a move to Liverpool, the Premier League champions, and has made it clear that his relationship with Newcastle is "broken" due to "broken promises."
Howe's team has been trying to sign a new striker all summer, but has been turned down by several players who have joined other Premier League clubs.
Speaking ahead of the upcoming match against Liverpool, Howe expressed his hope that Newcastle will sign a new striker, regardless of whether Isak stays or leaves the club.
He emphasized that the team cannot start the season without a recognized striker, and praised Will Osula, who is doing well but lacks experience in the Premier League.